Revivelife Clinic I Naturopath in Ottawa

iv max-SKIN LIGHTENING

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  • Reduces Oxidative Damage
  • Supports Liver Health
  • Skin Lightening & Brightening

HELPS

  • Longevity
  • Chemotherapy Recovery
  • Skin Beauty & Acne

FREQUENCY

  • Tailored to you. Commonly once a week until therapeutic results are obtained (4-8 treatments)
  • Reassessment and then maintenance monthly.

Glutathione is an antioxidant that reduces free radical damage and inflammation. It can improve acne, brain health, recovery, reduce side effects from chemotherapy, lifestyle diseases, and improve longevity.1-43   

Fun Fact: Also, known as the “Beyonce” due to its skin lightening, brightening & evening skin tone properties.44

HOW DOES THE IV MAX-SKIN LIGHTENING WORK?

Glutathione can help detoxification and skin tone. The color of your skin is determined by the amount of melanin under your skin. The more melanin the darker your skin. This formula is designed to synergistically work to prevent the amino acids in your body from mixing with the enzymes that produce melanin and repair cells that have suffered oxidative damage.44 As a result, your skin may look naturally lighter with even pigmentation. 44 Note potential skin lightening requires multiple sessions and results may vary.

faqs

Ingredients IV Max – Fuel G: Glutathione (601-2500mg) (once weekly x10)

Optional: Skin Lightening Add On Protocol

Ingredients IV Max – Skin Lightening Nutrients: B Vitamins, Vitamin C, Magnesium, Manganese, Selenium, Zinc, Carnitine, Glutamine, Glycine, Lysine, NAC, Proline, Taurine (once weekly x 5 alternating with)

Ingredients IV Max – Fuel C: Vitamin C 20-80g (once weekly x5)

  • Glutathione is the body’s master antioxidant, supports detoxification, and can help reduce and brighten skin tone.44,45
  • B Vitamins boost metabolism; energy; promote neurotransmitter production for optimal brain and mood; help to reduce the impact of stress on the body; and support healthy collagen and connective tissue to promote healthy hair and skin.46-50
  • Biotin supports the production of keratin for optimal hair, skin, and nail health.51,52 
  • Vitamin C is an antioxidant, reduces inflammation, stabilizes cell membranes, promotes skin healing, and forms collagen.53-55
  • Calcium: Both calcium and vitamin C, are responsible for the differentiation of keratinocytes, a major cell type in the epidermis of the skin. Reduced levels can contribute to dryness of the skin.56,57
  • Copper: Copper acts as an antioxidant, and stimulates the maturation of collagen, thus is critical in improving skin elasticity. and thickness.58
  • Magnesium: Magnesium helps to reduce the effects of stress, inflammation, free radical damage, and insulin resistance for improved skin health.59,60
  • Chromium is a mineral that supports balanced blood sugar, which can help reduce cravings and support the health of the skin.61
  • Manganese is a mineral that is a strong antioxidant and may reduce disease risk.62
  • Selenium is an antioxidant, promotes immunity, and supports thyroid function which influences hair, skin, and nails. Research has shown that it helps to protect the skin from UV- induced cell damage, skin inflammation, and pigmentation.63
  • Zinc is an antioxidant, anti-inflammatory, modulates the immune system, promotes wound healing, reduces the production of excess sebum, and is antibacterial against P. acnes the bacteria linked to acne.64,65
  • Carnitine (L-Acteyl-Carnitine) may help reduce the aging process of the skin.66
  • Glutamine increases the production of collagen to promote healthy skin, hair, and nails.67
  • Glycine increases collagen synthesis to support healthy, skin, hair, nails, and joint health.68
  • Lysine absorbs calcium which helps in the formation of collagen which is essential for forming the basic structure of hair follicles, strengthening hair shafts, and boosting hair growth in general. Lysine also helps to stop 5-alpha reductase from converting to testosterone into DHT, which is the main cause of male pattern baldness.69
  • N-Acetyl-Cysteine (NAC) is an antioxidant, anti-inflammatory, supports neurotransmitters, promotes vasodilation through increasing nitric oxide, helps to treat alopecia, and provides Sulphur to hair cells to improve their texture and strength.70
  • Proline is an amino acid that works with glutamine, glycine, and lysine to promote collagen synthesis.71
  • Taurine is an amino acid that has anti-aging properties, supports healthy hair growth, and helps to reduce fine lines and wrinkles in the skin.72,73

OPTIONAL ADD-ON

  • IM Fuel D: Vitamin D supports keratinocytes, follicle growth cycle, skin barrier function, and helps to reduce skin infections.74
  • IM CoQ10: CoQ10 positively influences the age-affected cellular metabolism and reduces the signs of skin aging at the cellular level.75

 

This mini version of our powerful glutathione IV can be used alone or added to our other formulas. Glutathione is the body’s master antioxidant.

Ingredient: Glutathione

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  8. Cascinu S, Labianca R, Alessandroni P, et al. Intensive weekly chemotherapy for advanced gastric cancer using fluorouracil, cisplatin, epi-doxorubicin, 6S-leucovorin, glutathione, and filgrastim: a report from the Italian Group for the Study of Digestive Tract Cancer. J Clin Oncol 1997;15:3313-9.
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  15. Graziano F, Cardarelli N, Marcellini M, et al. A pilot clinical trial of postoperative intensive weekly chemotherapy using cisplatin, epi-doxorubicin, 5-fluorouracil, 6S-leucovorin, glutathione and filgrastim in patients with resected gastric cancer. Tumori 1998;84:368-71.
  16. Hagen TM, Wierzbicka GT, Bowman BB, et al. Fate of dietary glutathione: disposition in the gastrointestinal tract. Am J Physiol 1990;259(4 Pt 1):G530-5.
  17. Jenner P, Olanow CW. Understanding cell death in Parkinson’s disease. Ann Neurol 1998;44(3 Suppl 1):S72-84.
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  20. Knapen MF, Peters WH, Mulder TP, et al. Glutathione and glutathione-related enzymes in decidua and placenta of controls and women with pre-eclampsia. Placenta 1999;20:541-6.
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  30. Merad-Boudia M, Nicole A, Santiard-Baron D, et al. Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson’s disease. Biochem Pharmacol 1998;56:645-55.
  31. Parnis FX, Coleman RE, Harper PG, et al. A randomized double-blind placebo-controlled clinical trial assessing the tolerability and efficacy of glutathione as an adjuvant to escalating doses of cisplatin in the treatment of advanced ovarian cancer. Eur J Cancer 1995;31A:1721.
  32. Pearce RK, Owen A, Daniel S, et al. Alterations in the distribution of glutathione in the substantia nigra in Parkinson’s disease. J Neural Transm 1997;104:661-77.
  33. Plaxe S, Freddo J, Kim S, et al. Phase I trial of cisplatin in combination with glutathione. Gynecol Oncol 1994;55:82-6.
  34. Powers SK, Hamilton K. Antioxidants and exercise. Clin Sports Med 1999;18:525-36.
  35. Powers SK, Ji LL, Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: a brief review. Med Sci Sports Exerc 1999;31:987-97.
  36. Roum JH, Borok Z, McElvaney NG, et al. Glutathione aerosol suppresses lung epithelial surface inflammatory cell-derived oxidants in cystic fibrosis. J Appl Physiol 1999;87:438-43.
  37. Ruffmann R, Wendel A. GSH rescue by N-acetylcysteine. Klin Wochenschr 1991;69:857-62.
  38. Samiec PS, Drews-Botsch C, Flagg EW, et al. Glutathione in human plasma: a decline in association with aging, age-related macular degeneration, and diabetes. Free Radic Biol Med 1998;24:699-704.
  39. Sechi G, Deledda MG, Bua G, et al. Reduced intravenous glutathione in the treatment of early Parkinson’s disease. Prog Neuropsychopharmacol Biol Psychiatry 1996;20:1159-70.
  40. Smyth JF, Bowman A, Perren T, et al. Glutathione reduces the toxicity and improves the quality of life of women diagnosed with ovarian cancer treated with cisplatin: results of a double-blind, randomized trial. Ann Oncol 1997;8:569-73.
  41. Usberti M, Lima G, Arisi M, et al. Effect of exogenous reduced glutathione on the survival of red blood cells in hemodialyzed patients. J Nephrol 1997;10:261-5.
  42. Walsh SW, Wang Y. Deficient glutathione peroxidase activity in preeclampsia is associated with increased placental production of thromboxane and lipid peroxides. Am J Obstet Gynecol 1993;169:1456-61.
  43. Witschi A, Reddy S, Stofer B, et al. The systemic availability of oral glutathione. Eur J Clin Pharmacol 1992;43:667-9.
  44. Dilokthornsakul W, Dhippayom T, Dilokthornsakul P, et al, The clinical effect of glutathione on skin color and other related skin conditions: A systematic review, J Cosmet Dermatol. 2019.
  45. Lang CA, The Impact of Glutathione on Health and Longevity, J of Anti-Aging Medicine, July 2004, 4 (2)
  46. Ford TC, Downey LA, Simpson T, et al, The Effect of a high-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Controlled Trial, Nutrients. 2018 Dec;10(12):1860
  47. Gehring W, Nicotinic acid niacinamide and the skin, J Cosmet Dermatol. 2004 Apr;3(2):88-93
  48. Higdon J. Linus Pauling Institute. Micronutrient Information Center. Pantothenic Acid: Wound Healing. http://lpi.oregonstate.edu/mic/vitamins/pantothenic-acid#wound-healing-treatment. Last updated 7/2015b. Accessed 2/3/2020, Accessed 2,3,2020
  49. Yang M, Moclair B, Hatcher V, et al, A Randomized, Double-Blind, Placebo-Controlled Study of a Novel Pantothenic Acid-Based Dietary Supplement in Subjects with Mild to Moderate Facial Acne, Dermatol Ther (Heidelb). 2014 Jun; 4(1):93-101.
  50. Prasad R, Lakshmi AV, BAmji MS, Impaired collagen maturity in vitamins B2 and B6 deficiency – probable molecular basis of skin lesions, Biochem Med. 1983 Dec;30(3):333-41.
  51. Zempleni J, Hassan YI, Wijeratne SS, Biotin and biotinidase deficiency. Expert Rev Endocrinol Metab. 2008 Nov 1;3(6):715-724.
  52. Hochman LG, Scher RK, Meyerson MS. , Brittle nails: response to daily biotin supplementation. Cutis. 1993 Apr;51(4):303-5.
  53. Moores J, Vitamin C: a wound healing perspective, Br J Community Nurs. 2013 Dec; Suppl:S6,S8-11
  54. Telang PS, Vitamin C in dermatology, Indian Dermatol Online J. 2013 Apr-June; 4(2):143-146
  55. Trueb RM, Oxidative Stress in Ageing of Hair, Int J Trichology. 2009 Jan-Jun;1(1):6-14
  56. Bikle D, TEichert A, Hawker N, et al, Sequential regulation of keratinocyte differentiation by 1,25(OH)2D3, VDR, and its coregulators. J Steroid Biochem Mol Biol. 2007;103:396-404
  57. Cosgrove MC, Franco OH, Granger  SP, et al, Dietary nutrient intakes and skin-aging appearance among middle-aged American women. Am J Clin Nutr. 2007;86:1225-1231
  58. Pickart L, Vasquez-Soltero JM, Margolina A. The human tripeptide GHK-Cu in the prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxid Med Cell Longev. 2012;2012:324832.
  59. Chiu A, Chon SY, Kimball AB. The response of skin disease to stress: Changes in the severity of acne vulgaris as affected by examination stress. Arch Dermatol. 2003;139 (7):897-900
  60. Geiger H, Wanner C. Magnesium in disease. Clin Kidney J. 2012;5 (1)125-138
  61. A scientific review: the role of chromium in insulin resistance. Diabetes Educ. 2004; Suppl:2-14
  62. Yasul K, Baba A, Therapeuic potential of superoxide dismutase (SOD) for resolution of inflammation. Inflamm Res, 2006 Sep;55(9):359-63
  63. Park K, Role of Micronutrients in Skin Health and Function, Biomol Ther (Seoul). 2015 May; 23(3):207-217.
  64. Brandt S. The clinical effects of zinc as a topical or oral agent on the clinical response and pathophysiologic mechanisms of acne: a systematic review of the literature. J of drugs in dermat: JDD. May 2013;12(5):542-545
  65. Brocard A, Dreno B. Innate immunity: a crucial target for zinc in the treatment of inflammatory dermatosis. J of the Europ A of Derm and VEnereol: JEADV. Oct 2011;25(10):1146-1152
  66. Baldassarri P, Calvani M, The aging process of the skin and the increase in the size of subcutaneous adipocytes.  Int J Tissue React. 1994; 16 (5-6):229041
  67. Karna E, Miltyk W, Wolczynski S, et al, The potential mechanism for glutamine-induced collagen biosynthesis in cultured human skin fibroblasts, Comp Biochem Physiol B Biochem Mol Biol. 2001 Aug; 130(1):23-32.
  68. De Paz-Lugo P, Lupianex JA, and Melendex-Hevia E, High glycine concentration increases collagen synthesis by articular chondrocytes in vito: acute glycine deficiency could be an important cause of osteoarthritis, Amino Acids. 2018; 50(10): 1357-1365.
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  72. Collin C, Gautier B, Gaillard O, et al. Protective effects of taurine on human hair follicle grown in vitro. Int J Cosmet Sci. 2006 Aug; 28(4):289-98
  73. Siefken W, HOger P et al, Role of Taurine Accumulation in Keratinocyte Hydration, J of Invest Dermatol, 121(2), August 2003, 354-361
  74. Piotrowska A, Wierzbicka J, Zmijewski MA, Vitamin D in the skin physiology and pathology. Acta Biochim Pol. 2016;63(1):17-29.
  75. Prahl S, Kueper T, Biernoth T, et al, Aging skin is functionally anaerobic: the importance of coenzyme Q 10 for anti-aging skin care. Biofactors. 2008;
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