Ingredients: B Vitamins, Vitamin B5, Vitamin B6, HydroxyB12 (active B12), 5-MTHF (active folate), Vitamin C, Chromium, Copper, Magnesium, Manganese, Selenium, Zinc, Taurine

• B Vitamins support cellular energy, detoxification, and mood; B1, B2, B3 are important for brain health, B5 promotes hormone production, B6 helps tryptophan convert to serotonin for a healthy mood, and Folate and B12 create new cells, promote energy production and are vital for the central nervous system.^4,5
• Vitamin B5 is required for the formation of all hormones.
• Vitamin B6 supports the conversion of tryptophan to serotonin to melatonin for optimal mood and sleep.
• HydroxyB12 is an active form of vitamin B12 for energy and mood
• 5-MTHF is the active form of folic acid for energy and mood.
• Vitamin C buffers nerve cell damage in depression, helps reduce anxiety, and is an important cofactor in the synthesis of serotonin, norepinephrine, and the adrenal hormones that improve the ability to cope with everyday stressors, and research shows that 15g of IVC can correct red blood cell abnormalities in 100% of people with chronic fatigue syndrome (DFS) within minutes.^6,7
• Calcium is vital for bone building, relaxing smooth muscles, and a steady state of calcium flow between cells is needed for cellular energy.⁸
• Chromium may contain mood stabilizing properties as well as antidepressant effect.⁹
• Copper and zinc imbalances may cause mood disorders, ADHD, anger problems, and more.^10,11
• Magnesium helps energy, anxiety, depression, muscle spasms, pain, energy, heart health, migraines, and asthma.^12,13
• Manganese can bind to neurotransmitters and stimulate faster or more efficient movement of electrical impulses throughout your body. As a result, brain function and mood may be improved.¹⁴
• Selenium is an antioxidant needed for immunity, thyroid health, glutathione production, reduction of inflammation, and helps restore imbalances in circadian rhythm to promote sleep and reduce the effects of stress^15-17
• Zinc is involved with copper in mood stabilization.¹⁸ In addition it helps immunity, wound healing, protection against oxidative damage, reducing inflammation, and may improve athletic performance by action on thyroid and testosterone hormones.¹⁹
• Taurine is an amino acid that stimulates new brain cell formation, and can help improve mood and brain health²⁰

OPTIONAL ADD ONS

• IM Fuel D: Vitamin D helps to support mood including depression, and reduce fatigue, inflammation, oxidative stress, and cardiovascular disease.^21,22

Get your smile on with our B vitamins and magnesium mini shot.

Ingredients: B Vitamins, MethylB12 (active B12), 5-MTHF (active folate), Magnesium, Glycine, Taurine

1. Eby GA, Eby KL. Magnesium for treatment-resistant depression: a review and hypothesis. Medical Hypotheses 2010;74(4):649-60.
2. Murphy SE, Longhitano C et al. Tryptophan supplementation induces a positive bias in the processing of emotional material in healthy female volunteers. Psychopharmacology (Berl). 2006 Jul;187(1):121–30.
3. Adams PW, Rose DP, et al. Effect of pyridoxine hydrochloride (vitamin B6) upon depression associated with oral contraceptives. Lancet 1973;1:897-904.
4. Woolf K, Manore MM. B-vitamins and exercise: does exercise alter requirements?  Int J Nutr Exerc Metab 2006;16:453-484.
5. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet neurology. Nov 2006;5(11):949-960.
6. de Oliverira IJ, de Souza VV, Motta V, et al, Effects of Oral Vitamin C Supplementation on Anxiety in Students: A Double-Blind, Randomized, Placebo-Controlled Trial, Pak J Biol Sci. 2015 Jan;18(1):11-8
7. Werbach MR. Nutritional strategies for treating chronic fatigue syndrome. Alt Med Rev 2000;5:93-108.
8. Cardenas C, Miller RA, Smith I, et al, Calcium Needed for Cell Energy Production, Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2 Transfer to Mitochondria. Cell 2010 July 23,2010 Cell 142(2) 270-283
9. Malcolm N, McLeod, and Golden RN, Chromium treatment of depression, I J of Neuropsychopharmacology 2000, 3, 311-314
10. Howard J, Zinc and Copper levels are key factors in ADD and ADHD, ACAM; American College for Advancement in Medicine, December 10, 2009
11. Styczen K, Sowa-Kucma, Siwek M, Study of the Serum Copper Levels in Patients with Major Depressive Disorder, Biol Trace Elem Res. 2016;174(2):287-293
12. Wicks TC. AANA Journal course: update for nurse anesthetists–magnesium homeostasis and deficiency. AANA journal. Apr 1999;67(2):171-179.
13. Cox IM, Campbell MJ, Dowson D.  Red blood cell magnesium and chronic fatigue syndrome.  Lancet 1991;337:757-760.
14. Takeda A, Manganese action in brain function, Brain Res Brain Res Rev, 2003 Jan;41(1):79-87
15. Kiremidjian-Schumacher L, Roy M, Wishe HI, et al, Supplementation with selenium and human immune cell functions. II. Effect on cytotoxic lymphocytes and natural killer cells, Biol Trace Elem Res. 1994 Apri-May;41(102):115-27
16. Drutel A, Archambeaud F, Caron P, Selenium and the thyroid gland: more good news for clinicians, Clin Endocrinol (Oxf). 2013 Feb;78(2):155-64
17. Duntas LH, Selenium and inflammation: underlying anti-inflammatory mechanisms, Hormone Metab Res. 2009 Jun;41(6):443-7.
18. Tate DJ, Jr., Miceli MV, Newsome DA. Zinc protects against oxidative damage in cultured human retinal pigment epithelial cells. Free radical biology & medicine. Mar 1999;26(5-6):704-713.
19. Kilic M.  Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with oral zinc. Neuro Endocrinol Lett 2007;681-685.
20. Hoeck AD, Pall ML. Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue? Medical hypotheses. Feb 2011;76(2):208-213.
21. Jorde R, Sneve M, et al. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. J Intern Med 2008;264;599-609
22. Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome is related to fatigue, autonomic, and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorders. Neuoendrocrinol Lett 2009;30:470-478.