Revivelife Clinic I Naturopath in Ottawa



  • Restores Nutrients
  • Supports MTHFR enzyme
  • Promotes Detoxification and Longevity


  • Methylation
  • Autoimmune Conditions


  • Tailored to you. Commonly once a week until therapeutic results are obtained (4-8 treatments)
  • Reassessment and then maintenance monthly.

This drip may support the MTHFR enzyme which breaks down homocysteine and folate in your body while helping to reduce symptoms of the MTHFR gene mutation.1 These may include imbalances in detoxification, immunity, cellular repair, energy, mood, inflammation, memory, and sleep.


Methylation is a biochemical process involving the transfer of an active methyl group (one carbon and three hydrogen atoms) between molecules. Methyl groups are billions of little on and off switches that regulate healing, energy, the stress response, detoxification through the formation and recycling of glutathione, inflammation, genetic expression and repair of DNA, neurotransmitters for mood and brain chemistry, histamine clearance, hormone clearance, phospholipid synthesis, myelination of peripheral nerves, homocysteine (an unhealthy compound that can damage blood vessels), and the immune response.

Certain genetic conditions leading to abnormalities in the methylation pathway, compounded with additional stressors such as nutrient deficiencies, environmental toxins and infectious agents, are linked to many illnesses including brain, behavior, and mood disorders caused by neurotransmitter imbalances, histamine intolerance, hormone imbalances, infertility, autoimmune conditions (multiple sclerosis, arthritis, etc), chronic fatigue syndrome (CFS), osteoporosis, diabetes, cervical dysplasia, cancer, depression, dementia, stroke, cardiovascular disease, and neural tube defects. Nutrient deficiencies are one of the primary causes of impaired methylation.


Ingredients: B Vitamins, Vitamin B5, Vitamin B6, Hydroxy B12 (active B12), MethylB12 (active B12), 5-Methyltetrahydrofolate (active folic acid) , Vitamin C, Calcium, Chromium, Copper, Magnesium, Manganese, Selenium, Zinc, Taurine

  • B Vitamins in particular vitamins B2, B6, folate, and B12 are key methyl donors, play essential roles in methyl group metabolism and DNA methylation in particular.2
  • Vitamin B5 is required to manufacture all hormones.
  • Vitamin B6 is required for the conversion of tryptophan to serotonin to melatonin for optimal mood and sleep.
  • Hydroxycobalamin (Hydroxy B12) can be readily converted in the body into the active forms of adenosylcobalamin and methylcobalamin. It supports detoxification pathways, is involved in the energy production process, and assists the brain and nervous system. This form of B12 is recommended in certain genetic methylation conditions.
  • Methylcobalamin (Methyl B12) is an active form of B12 that functions in the cell plasma as a coenzyme in the methylation cycle to synthesize amino acids, produce red blood cells, repair DNA, and assists in other important biological processes. Both hydroy B12 and methyl B12 have been included to promote optimal levels of a variety of B12.
  • 5-Methyltetrahydrofolate (5-MTHF) is an active form of folate that is required in the methionine cycle of the methylation process.3
  • Vitamin C is an antioxidant that donates electrons to activate enzymes containing iron or copper. This promotes methylation/demethylation balance (turning on gene expression) to make collagen, and furnishing L-carnitine and norepinephrine.4
  • Calcium supports relaxation of muscles.
  • Chromium helps to regulate blood sugar.
  • Copper is required for optimal adrenal and immune function.
  • Magnesium is a cofactor that is required in methylation for the production of SAM-e, glutathione, the folate cycle, neurotransmitters, and the formation of nitric oxide a vasodilator for healthy heart function.3
  • Manganese is a mineral that is key to support energy production.
  • Selenium plays an important role in the production of glutathione which is the body’s master antioxidant.3
  • Zinc deficiencies in zinc lead to a marked reduction in DNA methylation and increased inflammatory response.3,5
  • Taurine helps to reduce cortisol, calms the nervous system by facilitating the production of the neurotransmitter GABA, improves fat burning, improves insulin sensitivity, supports testosterone production, fights oxidative stress, supports phospholipid methylation during brain development, protects cardiovascular health and enhances athletic performance and recovery.6

Note – formulas may be modified occasionally.


  • IV Fuel G: Glutathione is the body`s master antioxidant made from the amino acids cysteine, glycine, and glutamine. It is recycled via methylation using methyl donors like vitamin B12, folate, betaine, and other nutrients.8 Glutathione contains sulfur groups, which are sticky compounds that bind to toxins and heavy metals and carry them out of the body.8 It neutralizes free radicals, reduces inflammation, and assists other antioxidants perform like Vitamin C, E, and lipoic acid.7

This IM shot delivers B vitamins in their active form to support methylation.

Ingredients: B Vitamins, Methyl & Hydroxy B12, 5-MTHF (active folate), Biotin, Chromium

  1. Fernandes SP, Kvitko K, da Silva J, et al, Susceptibility to DNA damage in workers occupationally exposed to pesticides, to tannery chemicals and to coal dust during mining. Int J Occup Environ Health. 2017 Oct;23(4):311-318
  2. Huang T, Zheng Y, Qi Q et al, DNA Methylation Variants at HIF3A Locus, B Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts, Diabetes. 2015 Sep;64(9):3146-3145
  3. Anderson OS, Sant KE, Dollinoy DC, Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation, The J of Nutr Biochem 23(8), August 2012 853-859
  4. Chong tL, Ahearn EL, and Cimmino L, Reprogramming the Epigenome With Vitamin C, Front Cell Dev Biol. 2019; 7: 128.
  5. Wallwork JC, Duerre JA, Effect of zinc deficiency on methionine metabolism, methylation reactions, and protein synthesis in isolated perfused rat liver. J Nutr. 1985 Feb; 115(2):252-62
  6. Lleu PL, Huxtable RJ, Phospholipid methylation and taurine content of synaptosomes from the cerebral cortex of developing rat, Neurochem Int 21(1) July 1992, 109-118
  7. Garcia-Gimenez JL and Pallardo FV, Maintenance of glutathione levels and its importance in epigenetic regulation, Front Pharmacol. 2014;5:88
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